Novel proteomic signatures may indicate MRI-assessed intrahepatic fat state and changes: The DIRECT PLUS clinical trial.
Dana T GoldbergAnat Yaskolka MeirGal TsabanEhud RinottAlon KaplanHila ZelichaNora KlötingUta CeglarekBerend IsermanIlan ShelefPhilip RosenMatthias BlüherMichael StumvollOhad EtzionMeir J StampferFrank B HuIris ShaiPublished in: Hepatology (Baltimore, Md.) (2024)
Our findings suggest novel proteomic signatures that may indicate MRI-assessed IHF state and changes during lifestyle intervention. Specifically, carbonic anhydrase 5A, hydroxyacid oxidase 1, and thrombospondin-2 protein changes are independently associated with IHF% change, and thrombospondin-2 protein change is greater in the green-MED/high polyphenols diet.
Keyphrases
- clinical trial
- contrast enhanced
- magnetic resonance imaging
- physical activity
- weight loss
- randomized controlled trial
- genome wide
- protein protein
- diffusion weighted imaging
- adipose tissue
- metabolic syndrome
- cardiovascular disease
- binding protein
- label free
- computed tomography
- type diabetes
- gene expression
- open label