Enhancer variants associated with Alzheimer's disease affect gene expression via chromatin looping.

Masataka KikuchiNorikazu HaraMai HasegawaAkinori MiyashitaRyozo KuwanoTakeshi IkeuchiAkihiro Nakaya

Published in: BMC medical genomics (2019)

Our results suggest that non-coding AD SNPs may affect the function of enhancers thereby influencing the expression levels of surrounding or distant genes via chromatin loops. This result may explain how some non-coding AD SNPs contribute to AD pathogenesis.

Keyphrases

genome wide
gene expression
dna methylation
copy number
transcription factor
binding protein
poor prognosis
dna damage
lymph node
cognitive decline
genome wide association
mild cognitive impairment