An EYA3/NF-κB/CCL2 signaling axis suppresses cytotoxic NK cells in the pre-metastatic niche to promote triple negative breast cancer metastasis.

Sheera R Rosenbaum Connor J Hughes Kaiah M Fields Stephen Connor Purdy Annika Gustafson Arthur WolinDrake HamptonNicholas TurnerChristopher EbmeierJames C Costello Heide L Ford

Published in: bioRxiv : the preprint server for biology (2024)

EYA3 promotes metastasis of TNBC cells by promoting NF-kB-mediated CCL2 expression and inhibiting cytotoxic NK cells at the pre-metastatic niche, highlighting a potential therapeutic target in this subset of breast cancer.

Keyphrases

nk cells
signaling pathway
induced apoptosis
pi k akt
cell cycle arrest
squamous cell carcinoma
small cell lung cancer
liver fibrosis
lps induced
poor prognosis
liver injury
oxidative stress
nuclear factor
binding protein
endoplasmic reticulum stress
human health
cell proliferation