Viruses Associated with Acute Conjunctivitis in Vanuatu.
Kasso JohnsonFasihah TaleoKalbule WillieEdwin AmelMadopule NanuMarie AlguetJose WassPrudence RymillAnthony SolomonKevin RuderCindi ChenLina ZhongArmin HinterwirthDavid LiuThomas AbrahamGerami SeitzmanThomas LietmanThuy Doannull nullPublished in: The American journal of tropical medicine and hygiene (2023)
The first manifestation of a viral infection may be conjunctivitis. There are limited data on the etiology of viral conjunctivitis in Vanuatu, a country in the South Pacific Ocean. Patients presenting to one of two Vanuatu health centers with presumed infectious conjunctivitis were eligible if symptom onset was within 14 days of screening. Conjunctival and anterior nasal swabs were obtained and subjected to unbiased RNA deep sequencing (RNA-seq) to identify DNA and RNA viruses. For samples collected from May to November 2021, RNA-seq identified a viral etiology in 12/48 patients. Human adenovirus species were the most common viruses (58%) detected, followed by human herpes viruses (cytomegalovirus, varicella zoster virus, and human herpes 7 virus). Rhinovirus C, Epstein-Barr virus, and bocavirus were also detected. In summary, the etiology for viral conjunctivitis in Vanuatu appears broad. Unbiased testing may be useful for disease surveillance.
Keyphrases
- rna seq
- single cell
- epstein barr virus
- endothelial cells
- end stage renal disease
- sars cov
- ejection fraction
- chronic kidney disease
- newly diagnosed
- public health
- induced pluripotent stem cells
- prognostic factors
- mental health
- pluripotent stem cells
- intensive care unit
- liver failure
- nucleic acid
- machine learning
- genetic diversity
- risk assessment
- electronic health record
- drug induced
- patient reported outcomes
- social media
- mechanical ventilation
- gene therapy