Transcription factor Fli-1 impacts the expression of CXCL13 and regulates immune cell infiltration into the kidney in MRL/lpr mouse.

Shuzo SatoXian K ZhangNaoki MatsuokaYuya SumichikaKenji SaitoShuhei YoshidaHaruki MatsumotoJumpei TemmokuYuya FujitaTomoyuki AsanoKiyoshi Migita

Published in: Lupus science & medicine (2023)

Fli-1 regulates renal Sox4 mRNA expression and infiltration of CXCR5-positive cells as well as CXCL13/CD11b double-positive immune cells into the kidney, which affects CXCL13 expression and lupus-like nephritis.

Keyphrases

transcription factor
poor prognosis
induced apoptosis
systemic lupus erythematosus
stem cells
long non coding rna
disease activity
signaling pathway
rheumatoid arthritis
endoplasmic reticulum stress
pi k akt