Clinical Activity of TGF-β Inhibitor Vactosertib in Combination with Imatinib in Desmoid Tumors: A Multicenter Phase Ib/II Study.

Jin-Hee Ahn Jeeyun Lee Changhee Park Seung-Hoon Beom Seung Hyun Kim Young Han Lee Kum-Hee Yun Jeong Eun Kim Woo-Yeol Baek Yoon Dae Han Sang-Kyum Kim Hyang Joo Ryu Inkyung Jung JooHee Lee Hong In Yoon Hyo Song Kim

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2024)

The vactosertib and imatinib combination was well tolerated, with promising clinical activity in patients with progressive, locally advanced desmoid tumors. This is the first study investigating a novel target agent, a TGF-β inhibitor, in this rare and difficult-to-treat desmoid tumor.

Keyphrases

locally advanced
squamous cell carcinoma
transforming growth factor
multiple sclerosis
radiation therapy
clinical trial
cross sectional
epithelial mesenchymal transition