DBU-Catalyzed Aerobic CDC Reaction of Thiophenols.

Xuemin JiaXiao MaWei FengJi-Quan ZhangYong-Long ZhaoBing GuoLei TangYuan-Yong Yang

Published in: The Journal of organic chemistry (2022)

A convenient method was developed for the preparation of thiolated compounds via a DBU-catalyzed aerobic cross-dehydrogenative coupling (CDC) reaction. The established protocol is environmentally friendly and operationally simple. Substrates like (hetero)aryl acetates, (hetero)aryl ketones, and indoles could be transformed into the corresponding thiolated products in moderate to high yields and further applied in the preparation of bioactive compounds in a prefunctionalization-free manner.

Keyphrases

room temperature
high intensity
molecularly imprinted
cell cycle
randomized controlled trial
electron transfer
ionic liquid
fluorescent probe