Characterization of an APP/tau rat model of Alzheimer's disease by positron emission tomography and immunofluorescent labeling.
Thomas FilipSeverin MairingerJoerg NeddensMichael SaubererStefanie FlunkertJohann StanekThomas WanekNobuyuki OkamuraOliver LangerBirgit Hutter-PaierClaudia KuntnerPublished in: Alzheimer's research & therapy (2021)
We thoroughly characterized a novel APP/Tau rat model using combined PET imaging and immunofluorescence analysis. We observed an age-related increase in [11C]PiB and [18F]THK-5317 binding in several brain regions in the APP/Tau group but not in the ntg group. Although we were able to reveal a positive correlation between amyloid labeling and [11C]PiB regional brain uptake, we observed relatively low human tau and amyloid fibril expression levels and a somewhat unstable brain pathology which questions the utility of this animal model for further studies.
Keyphrases
- pet imaging
- positron emission tomography
- cerebrospinal fluid
- computed tomography
- resting state
- white matter
- endothelial cells
- poor prognosis
- cerebral ischemia
- multiple sclerosis
- binding protein
- cognitive decline
- single cell
- transcription factor
- dna methylation
- brain injury
- long non coding rna
- subarachnoid hemorrhage
- induced pluripotent stem cells