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Urine tumor DNA detection of minimal residual disease in muscle-invasive bladder cancer treated with curative-intent radical cystectomy: A cohort study.

Pradeep Singh ChauhanKevin ChenRamandeep K BabbraWenjia FengNadja PejovicArmaan NallicheriPeter K HarrisKatherine DienstbachAndrew AtkociusLenon MaguireFaridi QaiumJeffrey J SzymanskiBrian C BaumannLi DingDengfeng CaoMelissa A ReimersEric H KimZachary L SmithVivek K AroraAadel A Chaudhuri
Published in: PLoS medicine (2021)
utDNA MRD detection prior to curative-intent radical cystectomy for bladder cancer correlated significantly with pathologic response, which may help select patients for bladder-sparing treatment. utDNA MRD detection also correlated significantly with PFS. Furthermore, utDNA can be used to noninvasively infer TMB, which could facilitate personalized immunotherapy for bladder cancer in the future.
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