Urine tumor DNA detection of minimal residual disease in muscle-invasive bladder cancer treated with curative-intent radical cystectomy: A cohort study.
Pradeep Singh ChauhanKevin ChenRamandeep K BabbraWenjia FengNadja PejovicArmaan NallicheriPeter K HarrisKatherine DienstbachAndrew AtkociusLenon MaguireFaridi QaiumJeffrey J SzymanskiBrian C BaumannLi DingDengfeng CaoMelissa A ReimersEric H KimZachary L SmithVivek K AroraAadel A ChaudhuriPublished in: PLoS medicine (2021)
utDNA MRD detection prior to curative-intent radical cystectomy for bladder cancer correlated significantly with pathologic response, which may help select patients for bladder-sparing treatment. utDNA MRD detection also correlated significantly with PFS. Furthermore, utDNA can be used to noninvasively infer TMB, which could facilitate personalized immunotherapy for bladder cancer in the future.
Keyphrases
- muscle invasive bladder cancer
- loop mediated isothermal amplification
- prognostic factors
- end stage renal disease
- newly diagnosed
- real time pcr
- label free
- ejection fraction
- chronic kidney disease
- rectal cancer
- peritoneal dialysis
- spinal cord injury
- current status
- radiation therapy
- patient reported outcomes
- sensitive detection
- combination therapy
- locally advanced
- quantum dots
- patient reported