Isoflavone Supplementation Does Not Potentiate the Effect of Combined Exercise Training on Resting and Ambulatory Blood Pressure in Non-Obese Postmenopausal Women: A Randomized Double-Blind Controlled Trial-A Pilot Study.
Juliene Gonçalves CostaIgor Moraes MarianoJéssica S GioloJaqueline P BatistaAna Luiza AmaralPaula A B RibeiroErick P de OliveiraGuilherme M PugaPublished in: Nutrients (2020)
Physical exercise and isoflavone supplementation are potential strategies to prevent and treat cardiovascular diseases in postmenopausal women. The aim of this study was to investigate whether there are additive effects of isoflavone supplementation when associated with combined aerobic and resistance exercise on resting and ambulatory blood pressure monitoring (ABPM) and in blood pressure variability (BPV). Thirty-one non-obese postmenopausal women were randomly allocated into two groups: placebo and exercise (Placebo n = 19); and isoflavone supplementation (100 mg/day) and exercise (isoflavone n = 19). ABPM and BPV were evaluated before and after 10 weeks of moderate combined (aerobic and resistance) exercise training. Generalized Estimating Equation (GEE) with Bonferroni correction and intention-to-treat analysis was used to compare the effects of interventions on resting BP, ABPM and BPV. Combined exercise training decreased resting systolic (SBP) and diastolic blood pressure (DBP) and reduced 24 h and awake ambulatory SBP, DBP and mean blood pressure over time, with no additional effects of isoflavone supplementation. No changes were observed in sleep period, or in BPV indexes (Standard Deviation of 24 h (SD), daytime and nighttime interval (SDdn) and average real variability (ARV) in both groups. We conclude that isoflavone supplementation does not potentiate the effects of combined training on resting and ambulatorial systolic and diastolic blood pressure in non-obese postmenopausal women.
Keyphrases
- blood pressure
- postmenopausal women
- heart rate
- bone mineral density
- hypertensive patients
- high intensity
- heart rate variability
- double blind
- physical activity
- metabolic syndrome
- adipose tissue
- type diabetes
- weight loss
- skeletal muscle
- cardiovascular disease
- blood glucose
- placebo controlled
- clinical trial
- sleep quality
- study protocol
- obese patients
- randomized controlled trial
- bariatric surgery
- open label
- coronary artery disease
- atrial fibrillation
- depressive symptoms