Chromone-Derived Polyketides from the Deep-Sea Fungus Diaporthe phaseolorum FS431.
Heng GuoZhao-Ming LiuYu-Chan ChenHai-Bo TanSai-Ni LiHao-Hua LiXiao-Xia GaoHong-Xin LiuWei-Min ZhangPublished in: Marine drugs (2019)
Five new chromone-derived polyketides phaseolorins A-F (1⁻5), together with nine known compounds, were isolated from the deep-sea derived fungus Diaporthe phaseolorum FS431. The structures of new compounds were determined by analysis of their NMR and high-resolution electrospray ionization mass spectroscopy (HRESIMS) spectroscopic data. The absolute configurations were confirmed by chemical transformations, extensively experimental electron capture detection (ECD) calculations, or X-ray crystallography. Among them, compound 2 represented the first example for a new family of chromone derivative possessing an unprecedented recombined five-member γ-lactone ring. Moreover, the new compounds (1⁻5) were evaluated for in vitro cytotoxic activities against a panel of human cancer cell lines.
Keyphrases
- high resolution
- mass spectrometry
- endothelial cells
- magnetic resonance
- electronic health record
- papillary thyroid
- high speed
- molecular docking
- magnetic resonance imaging
- multidrug resistant
- molecular dynamics simulations
- squamous cell carcinoma
- molecular dynamics
- machine learning
- density functional theory
- deep learning
- quantum dots
- real time pcr
- electron microscopy
- pluripotent stem cells