Antiviral Combination Clinically Better Than Standard Therapy in Severe but Not in Non-Severe COVID-19.
Prasan Kumar PandaBudha O SinghBikram MoirangthemYogesh Arvind BahurupiSarama SahaGirraj SainiMinakshi DharMukesh BairwaVenkatesh Srinivasa PaiAnkit AgarwalGirish SindhwaniShailendra HanduRavi KantPublished in: Clinical pharmacology : advances and applications (2021)
Though the results failed to show statistical superiority of the antiviral combination therapies to that of the standard therapy in both the severe and non-severe categories in symptomatic adult patients of COVID-19 due to very small sized trial, clinically hydroxychloroquine+ribavirin therapy is showing better recovery by 7.4% than standard therapy in the former category. However, results do indicate the benefit of standard therapy in the non-severe category by 6.6%. Furthermore, the dose of ribavirin needs to be reconsidered in the Indian population.