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Antiviral Combination Clinically Better Than Standard Therapy in Severe but Not in Non-Severe COVID-19.

Prasan Kumar PandaBudha O SinghBikram MoirangthemYogesh Arvind BahurupiSarama SahaGirraj SainiMinakshi DharMukesh BairwaVenkatesh Srinivasa PaiAnkit AgarwalGirish SindhwaniShailendra HanduRavi Kant
Published in: Clinical pharmacology : advances and applications (2021)
Though the results failed to show statistical superiority of the antiviral combination therapies to that of the standard therapy in both the severe and non-severe categories in symptomatic adult patients of COVID-19 due to very small sized trial, clinically hydroxychloroquine+ribavirin therapy is showing better recovery by 7.4% than standard therapy in the former category. However, results do indicate the benefit of standard therapy in the non-severe category by 6.6%. Furthermore, the dose of ribavirin needs to be reconsidered in the Indian population.
Keyphrases
  • early onset
  • coronavirus disease
  • sars cov
  • clinical trial
  • randomized controlled trial
  • stem cells
  • drug induced
  • mesenchymal stem cells
  • phase iii