Taurine-conjugated bile acids and their link to hepatic S1PR2 play a significant role in hepatitis C-related liver disease.
Rabab O AliJames A HaddadGabriella M QuinnGrace Y ZhangElizabeth TownsendLisa ScheuingKareen L HillMatthew MenkartJenna L OringherRegina UmarovaShakuntala RampertaapSergio D RosenzweigChristopher KohElliot B LevyDavid E KleinerOhad EtzionKareen L HillPublished in: Hepatology communications (2024)
Enhanced expression of hepatic S1PR2 in HCVi and HCVi-cirrhosis and strong associations of S1PR2 with Tau-BAs suggest pathological relevance of Tau-BA-hepatic S1PR2 signaling in chronic liver disease. These findings have therapeutic implications in chronic liver diseases.