Employing Cellulose Nanofiber-Based Hydrogels for Burn Dressing.
Aliakbar Tofangchi Kalle BastiMehdi JonoobiSima SepahvandAlireza AshoriValentina M SiracusaDavood RabieTizazu H MekonnenFatemeh NaeijianPublished in: Polymers (2022)
The aim of this research was to fabricate a burn dressing in the form of hydrogel films constructed with cellulose nanofibers (CNF) that has pain-relieving properties, in addition to wound healing. In this study, the hydrogels were prepared in the form of film. For this, CNF at weight ratios of 1, 2, and 3 wt.%, 1 wt.% of hydroxyethyl cellulose (HEC), and citric acid (CA) crosslinker with 10 and 20 wt.% were used. FE-SEM analysis showed that the structure of the CNF was preserved after hydrogel preparation. Cationization of CNF by C 6 H 14 NOCl was confirmed by FTIR spectroscopy. The drug release analysis results showed a linear relationship between the amount of absorption and the concentration of the drug. The MTT test (assay protocol for cell viability and proliferation) showed the high effectiveness of cationization of CNF and confirmed the non-toxicity of the resulting hydrogels.
Keyphrases
- wound healing
- drug release
- drug delivery
- hyaluronic acid
- ionic liquid
- randomized controlled trial
- tissue engineering
- chronic pain
- systematic review
- high resolution
- silver nanoparticles
- signaling pathway
- oxidative stress
- physical activity
- room temperature
- single molecule
- emergency department
- high throughput
- weight loss
- spinal cord injury
- extracellular matrix
- single cell
- adverse drug
- metal organic framework
- reduced graphene oxide