Prognostic Value of ER and PgR Expression and the Impact of Multi-clonal Expression for Recurrence in Ductal Carcinoma in situ: Results from the UK/ANZ DCIS Trial.
Mangesh A ThoratPauline M LeveyJ Louise JonesSarah E PinderNigel J BundredIan S FentimanJack M CuzickPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2021)
ER expression is a strong predictor of ipsilateral recurrence risk in DCIS. ER-positive DCIS with distinct ER-negative clones has a recurrence risk similar to ER-negative DCIS. ER should be routinely assessed in DCIS, and ER scoring should take clonality of expression into account.