Systematic Characterization of p53-Regulated Long Noncoding RNAs across Human Cancers Reveals Remarkable Heterogeneity among Different Tumor Types.

Kausik Regunath Vitalay Fomin Zhaoqi Liu Pingzhang Wang Mainul Hoque Bin Tian Raúl Rabadán Carol Prives

Published in: Molecular cancer research : MCR (2024)

Our results not only identify myriad p53-regulated long noncoding (lncRNA), they also reveal marked drug-induced, as well as tissue- and tumor-specific heterogeneity in these putative p53 targets and our findings have enabled the construction of robust classifiers for diagnosis and prognosis.

Keyphrases

drug induced
liver injury
single cell
endothelial cells
transcription factor
genome wide
long non coding rna
dna methylation
gene expression
adverse drug
electronic health record