Allergen-specific immunotherapy induces the suppressive secretoglobin 1A1 in cells of the lower airways.

Ulrich M ZisslerConstanze A JakwerthFerdinand GuerthLarissa LewitanSandra RothkirchMiodrag DavidovicMoritz UlrichMadlen OelsnerHolger Garn Carsten B Schmidt-Weber Adam M Chaker

Published in: Allergy (2021)

Allergen-specific immunotherapy induces a yet unknown local gene expression footprint in the lower airways that on one hand appears to be a result of multiple regulatory pathways and on the other hand reveals SCGB1A1 as novel anti-inflammatory mediator of long-term allergen-specific therapeutic intervention in the local environment.

Keyphrases

gene expression
cystic fibrosis
anti inflammatory
randomized controlled trial
induced apoptosis
dna methylation
transcription factor
cell cycle arrest
oxidative stress
cell death
signaling pathway