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Nanoparticle delivery of innate immune agonists combines with senescence-inducing agents to mediate T cell control of pancreatic cancer.

Loretah ChibayaChristina F LusiKelly D DeMarcoGriffin I KaneMeghan L BrassilChaitanya N ParikhKatherine C MurphyJunhui LiTiana E NaylorJulia CerruttiJessica PeuraJason R PitarresiJulie Lihua ZhuKatherine A FitzgeraldPrabhani U AtukoraleMarcus Ruscetti
Published in: bioRxiv : the preprint server for biology (2023)
Combining senescence-inducing MEK and CDK4/6 inhibitors with nanoparticle delivery of STING and TLR4 agonists leads to interferon-driven and cytotoxic T cell-mediated PDAC control.
Keyphrases
  • innate immune
  • dna damage
  • endothelial cells
  • toll like receptor
  • immune response
  • inflammatory response
  • stress induced
  • iron oxide
  • cell cycle
  • dendritic cells
  • pi k akt
  • signaling pathway