Nanoparticle delivery of innate immune agonists combines with senescence-inducing agents to mediate T cell control of pancreatic cancer.
Loretah ChibayaChristina F LusiKelly D DeMarcoGriffin I KaneMeghan L BrassilChaitanya N ParikhKatherine C MurphyJunhui LiTiana E NaylorJulia CerruttiJessica PeuraJason R PitarresiJulie Lihua ZhuKatherine A FitzgeraldPrabhani U AtukoraleMarcus RuscettiPublished in: bioRxiv : the preprint server for biology (2023)
Combining senescence-inducing MEK and CDK4/6 inhibitors with nanoparticle delivery of STING and TLR4 agonists leads to interferon-driven and cytotoxic T cell-mediated PDAC control.