Information growth for sequential monitoring of clinical trials with a stepped wedge cluster randomized design and unknown intracluster correlation.

Published in: Clinical trials (London, England) (2020)

Taking the study design into account and using either an estimate of the intracluster correlation from the ongoing study or other data in the same clusters should allow for easy implementation of group sequential methods in future stepped wedge designs.

Keyphrases

clinical trial
study protocol
open label
double blind
phase ii
phase iii
primary care
healthcare
placebo controlled
current status
electronic health record
randomized controlled trial
big data
quality improvement
machine learning
health information
artificial intelligence
social media