Chemo-enzymatic synthesis of glycolyl-ester-linked taxol-glucose conjugate, ie, 7-glycolyltaxol 2″-O-α-D-glucoside, was achieved by using α-glucosidase as a biocatalyst. The water-solubility of 7-glycolyltaxol 2″-O-α-D-glucoside (21 μM) was 53 fold higher than that of taxol. The hepatitis B virus envelope L particles (bio-nanocapsules) are effective for delivering 7-glycolyltaxol 2″-O-α-D-glucoside to human hepatocellular carcinoma NuE cells.
Keyphrases
- hepatitis b virus
- cancer therapy
- photodynamic therapy
- induced apoptosis
- hydrogen peroxide
- endothelial cells
- liver failure
- cell cycle arrest
- drug delivery
- combination therapy
- induced pluripotent stem cells
- molecular docking
- endoplasmic reticulum stress
- pluripotent stem cells
- squamous cell carcinoma
- cell death
- oxidative stress
- type diabetes
- signaling pathway
- blood glucose
- cell proliferation
- skeletal muscle
- molecular dynamics simulations
- rectal cancer