TPX2 Amplification-Driven Aberrant Mitosis in Culture Adapted Human Embryonic Stem Cells with gain of 20q11.21.

Ho-Chang JeongYoung-Hyun GoJoong-Gon ShinYun-Jeong KimMin-Guk ChoDasom GwonHyun Sub CheongHaeseung LeeJae-Ho LeeChang-Young JangHyoung Doo ShinHyuk-Jin Cha

Published in: Stem cell reviews and reports (2023)

These studies suggest that the increased transcription of TPX2 in culture adapted hESCs could contribute to an increase in aberrant mitosis due to altered spindle dynamics.

Keyphrases

embryonic stem cells
endothelial cells
transcription factor
pluripotent stem cells
nucleic acid