Ultrastructural, transcriptional, and functional differences between human reticulated and non-reticulated platelets.

Laura HilleMaximilian LenzAndreas VlachosBjörn GrüningLutz HeinFranz-Josef NeumannThomas G NührenbergDietmar Trenk

Published in: Journal of thrombosis and haemostasis : JTH (2020)

Our results demonstrate that altered intrinsic structural and molecular properties contribute to the hyperreactivity of RP. These properties and an increased amount of RP may account for the association with cardiovascular risk.

Keyphrases

endothelial cells
gene expression
transcription factor
induced pluripotent stem cells
pluripotent stem cells
single molecule
oxidative stress
red blood cell
electron microscopy
heat stress