Distinct structural and dynamic components of portal hypertension in different animal models and human liver disease etiologies.

Philipp KönigshoferBenedikt Silvester HoferKsenia BrusilovskayaBenedikt SimbrunnerOleksandr PetrenkoKatharina WöranMerima HeracJudith StiftKatharina LampichlerGerald TimelthalerDavid Josef Maria BauerLukas HartlBernhard RoblMaria SibilaBruno K PodesserGeorg OberhuberPhilipp SchwablMattias MandorferMichael TraunerThomas Reiberger

Published in: Hepatology (Baltimore, Md.) (2021)

The relative contribution of 'static' fibrosis on PH severity varies by type of liver injury. Next to hyperdynamic circulation, increased bile acids, VWF-Ag, IL-6 and HA seem to indicate a pronounced dynamic component of PH in patients.

Keyphrases

liver injury
drug induced
end stage renal disease
endothelial cells
ejection fraction
blood pressure
newly diagnosed
prognostic factors
quantum dots
pluripotent stem cells