Severe Communication Delays Are Independent of Seizure Burden and Persist Despite Contemporary Treatments in SCN1A+ Dravet Syndrome: Insights from the ENVISION Natural History Study.
Michael Scott PerryIngrid Eileen SchefferJoseph SullivanAndreas BrunklausSusana BoronatJames W WhelessLinda LauxAnup D PatelColin M RobertsDennis DlugosDeborah HolderKelly G KnuppMatt LallasSteven PhillipsEric SegalPatricia SmeyersDennis LalElaine C WirrellSameer ZuberiTobias BrüngerMary WojnaroskiBenit MaruPenrose O'DonnellMagda MortonEmma JamesMaria Candida VilaNorman HuangJacqueline S GofshteynSalvador RicoPublished in: Epilepsia (2023)
In infants and young children with SCN1A+ DS, language/communication delay and stagnation were independent of seizure burden. Our findings emphasize the optimal therapeutic window to prevent language/communication delay is before 3 years of age.