Long-term effects of photobiomodulation therapy on blood pressure in obese rats induced by a high-fat diet.
Jorge Camargo OishiLuis Henrique Oliveira de MoraesJulio Cesar Conceição FilhoThiago Francisco de MoraesBarbara TerroniCynthia Aparecida de CastroLuciana Almeida-LopesGerson Jhonatan RodriguesPublished in: Lasers in medical science (2024)
The main cardiovascular disease risk associated with obesity is hypertension. The therapeutic use of photobiomodulation therapy (PBM) is suggested for the treatment of wound healing, osteoarthritis, and arterial diseases. However, few studies have measured how red laser (at 660 nm) acts over hypertension, and any of those studies used experimental obesity model. The aim of the study was an attempt to evaluate the long-term effect of PBM on systolic blood pressure in an animal model of obesity, induced by a high-fat diet (HFD). Our results indicate that PBM carried out 3 days a week was able to prevent the increase in blood pressure (133.75 ± 4.82 mmHg, n = 8) induced by a high-fat diet (150.00 ± 4.57 mmHg, n = 8; p < 0.05), restore nitric oxide levels (control: 31.7 ± 5.5 μM, n = 8; HFD + PBM: 29.9 ± 3.7 μM, n = 8 > HFD: 22.2 ± 2.9 μM, n = 8, p < 0.05), decrease lipoperoxidation (control: 1.65 ± 0.25 nM, n = 8; HFD + PBM: 2.05 ± 0.55 nM, n = 8 < HFD: 3.20 ± 0.47 nM, n = 8; p < 0.05), and improve endothelial function (pD2 control: 7.39 ± 0.08, n = 8 > pD2 HFD + PBM: 7.15 ± 0.07, n = 8 > HFD: 6.94 ± 0.07, n = 8; p < 0.05). Our results indicate that PBM prevents the elevation of blood pressure in an obese animal model by a mechanism that involves improvement of endothelial function through an antioxidant effect.
Keyphrases
- high fat diet
- blood pressure
- insulin resistance
- adipose tissue
- metabolic syndrome
- weight loss
- type diabetes
- hypertensive patients
- high fat diet induced
- cardiovascular disease
- nitric oxide
- photodynamic therapy
- heart rate
- wound healing
- skeletal muscle
- blood glucose
- bariatric surgery
- weight gain
- rheumatoid arthritis
- clinical trial
- heart failure
- oxidative stress
- stem cells
- randomized controlled trial
- mass spectrometry
- glycemic control
- coronary artery disease
- cardiovascular events
- high resolution
- bone marrow
- left ventricular
- study protocol
- case control
- mouse model
- cardiovascular risk factors
- breast cancer risk
- nitric oxide synthase