The bromodomain protein inhibitor I-BET151 suppresses expression of inflammatory genes and matrix degrading enzymes in rheumatoid arthritis synovial fibroblasts.

Kerstin KleinPawel A KabalaAleksander M GrabiecRenate E GayChristoph KollingLih-Ling LinSteffen GayPaul P TakRab K PrinjhaCaroline OspeltKris A Reedquist

Published in: Annals of the rheumatic diseases (2014)

Inhibition of BET family proteins suppresses the inflammatory, matrix-degrading, proliferative and chemoattractive properties of RASF and suggests a therapeutic potential in the targeting of epigenetic reader proteins in RA.

Keyphrases

rheumatoid arthritis
signaling pathway
disease activity
oxidative stress
poor prognosis
binding protein
ankylosing spondylitis
gene expression
interstitial lung disease
cancer therapy
systemic lupus erythematosus
protein protein
long non coding rna
small molecule
genome wide identification