White matter fiber microstructure is associated with prior hospitalizations rather than acute symptomatology in major depressive disorder.

Susanne MeinertElisabeth J LeehrDominik GrotegerdJonathan ReppleKatharina FörsterNils R WinterVerena EnnekingStella M FingasHannah LemkeLena WaltemateFrederike SteinKatharina BroschSimon SchmittTina MellerAnna LingeAxel KrugIgor NenadićAndreas JansenTim HahnRonny RedlichNils OpelRicarda I SchubotzBernhard T BauneTilo KircherUdo Dannlowski

Published in: Psychological medicine (2020)

Decreased FA and increased MD and RD values in the SLF are associated with more hospitalizations when controlling for current psychopathology. SLF fiber integrity could reflect cumulative illness burden at a neurobiological level and should be targeted in future longitudinal analyses.

Keyphrases

major depressive disorder
white matter
bipolar disorder
multiple sclerosis
liver failure
respiratory failure
cancer therapy
molecular dynamics
cross sectional
drug induced
risk factors
aortic dissection