Sirt1 expression is associated with CD31 expression in blood cells from patients with chronic obstructive pulmonary disease.

Ryo KatoShiro MizunoMaiko KadowakiKohei ShiozakiMasaya AkaiKen NakagawaTaku OikawaMasaharu IguchiKazuhiro OsanaiTakeshi IshizakiNorbert F VoelkelHirohisa Toga

Published in: Respiratory research (2016)

Sirt1 expression in blood cells from patients with COPD could be a biomarker for disease stability in patients with moderate COPD. MiR-34a may participate in apoptosis and/or senescence of EPCs in smokers. Decreased expression of CD31, CD34, and miR-126-3p potentially represents decreased numbers of EPCs in blood cell from patients with COPD.

Keyphrases

poor prognosis
chronic obstructive pulmonary disease
long non coding rna
oxidative stress
binding protein
lung function
dna damage
single cell
endoplasmic reticulum stress
smoking cessation
bone marrow
long noncoding rna