Plasmatic HIV-1 soluble gp120 is associated with correlates of immune dysfunction and inflammation in ART-treated individuals with undetectable viremia.

Mehdi BenlarbiJonathan RichardCatherine BourassaWilliam D TolbertCarl Chartrand-LefebvreGabrielle Gendron-LepageMohamed SyllaMohamed El-FarMarc Messier-PeetCamille GuertinIsabelle TurcotteRémi FromentinMyriam Maude VerlyJérémie PrévostAndrew ClarkWalther MothesDaniel E KaufmannFrank MaldarelliNicolas ChomontPhilippe BéginCécile TremblayJean-Guy BarilBenoit TrottierSylvie TrottierRalf DuerrMarzena PazgierMadeleine DurandAndrés Finzi

Published in: The Journal of infectious diseases (2023)

sgp120 may act as a pan toxin causing immune dysfunction and sustained inflammation in a subset of PLWH, contributing to the development of premature comorbidities.

Keyphrases

oxidative stress
antiretroviral therapy
hiv infected
hiv positive
escherichia coli
human immunodeficiency virus
hepatitis c virus
hiv testing
hiv aids
men who have sex with men
south africa