Walther Mothes

ORCID

Publication Activity (10 Years)

Years Active: 2018-2024
Publications (10 Years): 29

Top Venues

Science advances

Proceedings of the National Academy of Sciences of the United States of America

Journal of virology

bioRxiv : the preprint server for biology

Yale University School of Medicine

This page only lists publications with an associated author ORCID identifier.

Affiliation History

Yale University School of Medicine Sep 01 2001

United States

Professor :: Microbial Pathogenesis

Publications

Christina Papini, Irfan Ullah, Amalendu P Ranjan, Shuo Zhang, Qihao Wu, Krasimir A Spasov, Chunhui Zhang, Walther Mothes, Jason M Crawford, Brett D Lindenbach, Pradeep D Uchil, Priti Kumar, William L Jorgensen, Karen S Anderson
Proof-of-concept studies with a computationally designed M pro inhibitor as a synergistic combination regimen alternative to Paxlovid. Proceedings of the National Academy of Sciences of the United States of America 121 (17) (2024)
Yuta Hikichi, Jonathan R Grover, Alicia Schäfer, Walther Mothes, Eric O Freed
Epistatic pathways can drive HIV-1 escape from integrase strand transfer inhibitors. Science advances 10 (9) (2024)
Michael W Grunst, Zhuan Qin, Esteban Dodero-Rojas, Shilei Ding, Jérémie Prévost, Yaozong Chen, Yanping Hu, Marzena E Pazgier, Shenping Wu, Xuping Xie, Andrés Finzi, José Nelson Onuchic, Paul Charles Whitford, Walther Mothes, Wenwei Li
Structure and inhibition of SARS-CoV-2 spike refolding in membranes. Science (New York, N.Y.) 385 (6710) (2024)
Yuta Hikichi, Jonathan R Grover, Alicia Schäfer, Walther Mothes, Eric O Freed
Epistatic pathways can drive HIV-1 escape from integrase strand transfer inhibitors. Science advances 10 (9) (2024)
Christina Papini, Irfan Ullah, Amalendu P Ranjan, Shuo Zhang, Qihao Wu, Krasimir A Spasov, Chunhui Zhang, Walther Mothes, Jason M Crawford, Brett D Lindenbach, Pradeep D Uchil, Priti Kumar, William L Jorgensen, Karen S Anderson
Proof-of-concept studies with a computationally designed M pro inhibitor as a synergistic combination regimen alternative to Paxlovid. Proceedings of the National Academy of Sciences of the United States of America 121 (17) (2024)
Christina Papini, Irfan Ullah, Amalendu P Ranjan, Shuo Zhang, Qihao Wu, Krasimir A Spasov, Chunhui Zhang, Walther Mothes, Jason M Crawford, Brett D Lindenbach, Pradeep D Uchil, Priti Kumar, William L Jorgensen, Karen S Anderson
Proof-of-concept studies with a computationally designed M pro inhibitor as a synergistic combination regimen alternative to Paxlovid. Proceedings of the National Academy of Sciences of the United States of America 121 (17) (2024)
Christina Papini, Irfan Ullah, Amalendu P Ranjan, Shuo Zhang, Qihao Wu, Krasimir A Spasov, Chunhui Zhang, Walther Mothes, Jason M Crawford, Brett D Lindenbach, Pradeep D Uchil, Priti Kumar, William L Jorgensen, Karen S Anderson
Proof-of-concept studies with a computationally designed M pro inhibitor as a synergistic combination regimen alternative to Paxlovid. Proceedings of the National Academy of Sciences of the United States of America 121 (17) (2024)
Yuta Hikichi, Jonathan R Grover, Alicia Schäfer, Walther Mothes, Eric O Freed
Epistatic pathways can drive HIV-1 escape from integrase strand transfer inhibitors. Science advances 10 (9) (2024)
Michael W Grunst, Zhuan Qin, Esteban Dodero-Rojas, Shilei Ding, Jérémie Prévost, Yaozong Chen, Yanping Hu, Marzena E Pazgier, Shenping Wu, Xuping Xie, Andrés Finzi, José Nelson Onuchic, Paul Charles Whitford, Walther Mothes, Wenwei Li
Structure and inhibition of SARS-CoV-2 spike refolding in membranes. Science (New York, N.Y.) 385 (6710) (2024)
Michael W Grunst, Zhuan Qin, Esteban Dodero-Rojas, Shilei Ding, Jérémie Prévost, Yaozong Chen, Yanping Hu, Marzena E Pazgier, Shenping Wu, Xuping Xie, Andrés Finzi, José Nelson Onuchic, Paul Charles Whitford, Walther Mothes, Wenwei Li
Structure and inhibition of SARS-CoV-2 spike refolding in membranes. Science (New York, N.Y.) 385 (6710) (2024)
Yuta Hikichi, Jonathan R Grover, Alicia Schäfer, Walther Mothes, Eric O Freed
Epistatic pathways can drive HIV-1 escape from integrase strand transfer inhibitors. Science advances 10 (9) (2024)
Irfan Ullah, Fanny Escudie, Ivan Scandale, Zoela Gilani, Gabrielle Gendron-Lepage, Fleur Gaudette, Charles E Mowbray, Laurent Fraisse, Renée Bazin, Andrés Finzi, Walther Mothes, Priti Kumar, Eric Chatelain, Pradeep D Uchil
Combinatorial Regimens Augment Drug Monotherapy for SARS-CoV-2 Clearance in Mice. bioRxiv : the preprint server for biology (2023)
María M Lorenzo, Alejandro Marín-López, Kevin Chiem, Luis Jiménez-Cabello, Irfan Ullah, Sergio Utrilla-Trigo, Eva Calvo-Pinilla, Gema Lorenzo, Sandra Moreno, Chengjin Ye, Jun-Gyu Park, Alejandro Matía, Alejandro Brun, Juana M Sánchez-Puig, Aitor Nogales, Walther Mothes, Pradeep D Uchil, Priti Kumar, Javier Ortego, Erol Fikrig, Luis Martinez-Sobrido, Rafael Blasco
Vaccinia Virus Strain MVA Expressing a Prefusion-Stabilized SARS-CoV-2 Spike Glycoprotein Induces Robust Protection and Prevents Brain Infection in Mouse and Hamster Models. Vaccines 11 (5) (2023)
Wenwei Li, Zhuan Qin, Elizabeth Nand, Michael W Grunst, Jonathan R Grover, Julian W Bess, Jeffrey D Lifson, Michael B Zwick, Hemant D Tagare, Pradeep D Uchil, Walther Mothes
HIV-1 Env trimers asymmetrically engage CD4 receptors in membranes. Nature (2023)
Mehdi Benlarbi, Jonathan Richard, Catherine Bourassa, William D Tolbert, Carl Chartrand-Lefebvre, Gabrielle Gendron-Lepage, Mohamed Sylla, Mohamed El-Far, Marc Messier-Peet, Camille Guertin, Isabelle Turcotte, Rémi Fromentin, Myriam Maude Verly, Jérémie Prévost, Andrew Clark, Walther Mothes, Daniel E Kaufmann, Frank Maldarelli, Nicolas Chomont, Philippe Bégin, Cécile Tremblay, Jean-Guy Baril, Benoit Trottier, Sylvie Trottier, Ralf Duerr, Marzena Pazgier, Madeleine Durand, Andrés Finzi
Plasmatic HIV-1 soluble gp120 is associated with correlates of immune dysfunction and inflammation in ART-treated individuals with undetectable viremia. The Journal of infectious diseases (2023)
Susan A Leonhardt, Michael D Purdy, Jonathan R Grover, Ziwei Yang, Sandra Poulos, William E McIntire, Elizabeth A Tatham, Satchal K Erramilli, Kamil Nosol, Kin Kui Lai, Shilei Ding, Maolin Lu, Pradeep D Uchil, Andrés Finzi, Alan Rein, Anthony A Kossiakoff, Walther Mothes, Mark Yeager
Antiviral HIV-1 SERINC restriction factors disrupt virus membrane asymmetry. Nature communications 14 (1) (2023)
Dijin Xu, Weiqian Jiang, Lizhen Wu, Ryan G Gaudet, Eui-Soon Park, Maohan Su, Sudheer Kumar Cheppali, Nagarjuna R Cheemarla, Pradeep Kumar, Pradeep D Uchil, Jonathan R Grover, Ellen F Foxman, Chelsea M Brown, Phillip J Stansfeld, Joerg Bewersdorf, Walther Mothes, Erdem Karatekin, Craig B Wilen, John D MacMicking
PLSCR1 is a cell-autonomous defence factor against SARS-CoV-2 infection. Nature (2023)
Ziwei Yang, Yang Han, Shilei Ding, Wei Shi, Tongqing Zhou, Andrés Finzi, Peter D Kwong, Walther Mothes, Maolin Lu
SARS-CoV-2 Variants Increase Kinetic Stability of Open Spike Conformations as an Evolutionary Strategy. mBio (2022)
Yaozong Chen, Lulu Sun, Irfan Ullah, Guillaume Beaudoin-Bussières, Sai Priya Anand, Andrew P Hederman, William D Tolbert, Rebekah Sherburn, Dung N Nguyen, Lorie Marchitto, Shilei Ding, Di Wu, Yuhong Luo, Suneetha Gottumukkala, Sean Moran, Priti Kumar, Grzegorz Piszczek, Walther Mothes, Margaret E Ackerman, Andrés Finzi, Pradeep D Uchil, Frank J Gonzalez, Marzena E Pazgier
Engineered ACE2-Fc counters murine lethal SARS-CoV-2 infection through direct neutralization and Fc-effector activities. Science advances 8 (28) (2022)
Irfan Ullah, Jérémie Prévost, Mark S Ladinsky, Helen M Stone, Maolin Lu, Sai Priya Anand, Guillaume Beaudoin, Kelly Symmes, Mehdi Benlarbi, Shilei Ding, Romain Gasser, Corby Fink, Yaozong Chen, Alexandra Tauzin, Guillaume Goyette, Catherine Bourassa, Halima Medjahed, Matthias Mack, Kunho Chung, Craig B Wilen, Gregory A Dekaban, Jimmy D Dikeakos, Emily A Bruce, Daniel E Kaufmann, Leonidas Stamatatos, Andrew T McGuire, Jonathan Richard, Marzena E Pazgier, Pamela J Bjorkman, Walther Mothes, Andrés Finzi, Priti Kumar, Pradeep D Uchil
Live Imaging of SARS-CoV-2 Infection in Mice Reveals Neutralizing Antibodies Require Fc Function for Optimal Efficacy. bioRxiv : the preprint server for biology (2021)
Wenwei Li, Yaozong Chen, Jérémie Prévost, Irfan Ullah, Maolin Lu, Shang Yu Gong, Alexandra Tauzin, Romain Gasser, Dani Vézina, Sai Priya Anand, Guillaume Goyette, Debashree Chaterjee, Shilei Ding, William D Tolbert, Michael W Grunst, Yuxia Bo, Shijian Zhang, Jonathan Richard, Fei Zhou, Rick K Huang, Lothar Esser, Allison Zeher, Marceline Côté, Priti Kumar, Joseph Sodroski, Di Xia, Pradeep D Uchil, Marzena Pazgier, Andrés Finzi, Walther Mothes
Structural Basis and Mode of Action for Two Broadly Neutralizing Antibodies Against SARS-CoV-2 Emerging Variants of Concern. bioRxiv : the preprint server for biology (2021)
Kelsey A Haugh, Mark S Ladinsky, Irfan Ullah, Helen M Stone, Ruoxi Pi, Alexandre Gilardet, Michael W Grunst, Priti Kumar, Pamela J Bjorkman, Walther Mothes, Pradeep D Uchil
In vivo imaging of retrovirus infection reveals a role for Siglec-1/CD169 in multiple routes of transmission. eLife 10 (2021)
Maolin Lu, Xiaochu Ma, Nick Reichard, Daniel S Terry, James Arthos, Amos B Smith, Joseph G Sodroski, Scott C Blanchard, Walther Mothes
Correction for Lu et al., "Shedding-Resistant HIV-1 Envelope Glycoproteins Adopt Downstream Conformations That Remain Responsive to Conformation-Preferring Ligands". Journal of virology 94 (22) (2020)
Ze Li, Wenwei Li, Maolin Lu, Julian Bess, Cara W Chao, Jason Gorman, Daniel S Terry, Baoshan Zhang, Tongqing Zhou, Scott C Blanchard, Peter D Kwong, Jeffrey D Lifson, Walther Mothes, Jun Liu
Subnanometer structures of HIV-1 envelope trimers on aldrithiol-2-inactivated virus particles. Nature structural & molecular biology 27 (8) (2020)
Maolin Lu, Xiaochu Ma, Nick Reichard, Daniel S Terry, James Arthos, Amos B Smith, Joseph G Sodroski, Scott C Blanchard, Walther Mothes
Shedding-Resistant HIV-1 Envelope Glycoproteins Adopt Downstream Conformations That Remain Responsive to Conformation-Preferring Ligands. Journal of virology 94 (17) (2020)
Shitao Zou, Shijian Zhang, Althea Gaffney, Haitao Ding, Maolin Lu, Jonathan R Grover, Mark Farrell, Hanh T Nguyen, Connie Zhao, Saumya Anang, Meiqing Zhao, Mohammadjavad Mohammadi, Scott C Blanchard, Cameron Abrams, Navid Madani, Walther Mothes, John C Kappes, Amos B Smith, Joseph Sodroski
Long-Acting BMS-378806 Analogues Stabilize the State-1 Conformation of the Human Immunodeficiency Virus Type 1 Envelope Glycoproteins. Journal of virology 94 (10) (2020)
John D Ventura, Jagadish Beloor, Edward J Allen, Tongyu Zhang, Kelsey A Haugh, Pradeep D Uchil, Christina Ochsenbauer, Collin Kieffer, Priti Kumar, Thomas J Hope, Walther Mothes
Longitudinal bioluminescent imaging of HIV-1 infection during antiretroviral therapy and treatment interruption in humanized mice. PLoS pathogens 15 (12) (2019)
Ruoxi Pi, Akiko Iwasak, Xaver Sewald, Walther Mothes, Pradeep D Uchil
Murine Leukemia Virus Exploits Innate Sensing by Toll-Like Receptor 7 in B-1 Cells To Establish Infection and Locally Spread in Mice. Journal of virology 93 (21) (2019)
Xiaochu Ma, Maolin Lu, Jason Gorman, Daniel S Terry, Xinyu Hong, Zhou Zhou, Hong Zhao, Roger B Altman, James Arthos, Scott C Blanchard, Peter D Kwong, James B Munro, Walther Mothes
HIV-1 Env trimer opens through an asymmetric intermediate in which individual protomers adopt distinct conformations. eLife 7 (2018)

Walther Mothes.css-eqlu8i{font-size:small;padding-left:4px;}

Publication Activity (10 Years)

Top Topics

Top Venues

Walther Mothes