fosM, a New Family of Fosfomycin Resistance Genes Identified in Bacterial Species Isolated from Human Microbiota.
Sami KhabthaniMouna HamelSophie Alexandra BaronSeydina M DieneJean-Marc RolainVicky MerhejPublished in: Antimicrobial agents and chemotherapy (2021)
Fosfomycin is a decades-old antibiotic, currently reused because of its activity against multidrug-resistant bacteria. Here, we used a combined in vitro/in silico approach to search for fosfomycin resistance determinants in 25 new bacterial species isolated from the human microbiota. Putative resistance genes were cloned into a susceptible Escherichia coli strain. MIC values increased from 1 μg/ml to 1,024 μg/ml. Here, we report a new family of potential chromosomal fosfomycin resistance genes, named fosM.
Keyphrases
- multidrug resistant
- gram negative
- endothelial cells
- escherichia coli
- urinary tract infection
- genome wide
- genome wide identification
- induced pluripotent stem cells
- pluripotent stem cells
- drug resistant
- dna methylation
- klebsiella pneumoniae
- copy number
- climate change
- pseudomonas aeruginosa
- molecular dynamics simulations
- biofilm formation