Comprehensive multi-omics integration identifies differentially active enhancers during human brain development with clinical relevance.

Soheil YousefiRuizhi DengKristina LankoEva Medico SalsenchAnita NikoncukHerma C van der LindeElena PerenthalerTjakko J van HamEskeatnaf MulugetaTahsin Stefan Barakat

Published in: Genome medicine (2021)

This compendium of high-confidence enhancers will assist in deciphering the mechanism behind developmental genetics of human brain and will be relevant to uncover missing heritability in human genetic brain disorders.

Keyphrases

genome wide
endothelial cells
resting state
induced pluripotent stem cells
single cell
pluripotent stem cells
dna methylation
copy number
functional connectivity
brain injury