Integrative epigenomic and high-throughput functional enhancer profiling reveals determinants of enhancer heterogeneity in gastric cancer.

Taotao ShengShamaine Wei Ting HoWen Fong OoiChang XuManjie XingNisha PadmanabhanKie Kyon HuangLijia MaMohana RayYu Amanda GuoNgak Leng SimChukwuemeka George Anene-NzeluMei Mei ChangMilad Razavi-MohseniMichael A BeerRoger Sik Yin FooRaghav SundarYiong Huak ChanAngie Lay Keng TanXuewen OngAnders Jacobsen SkanderupKevin P WhiteSudhakar JhaPatrick Boon-Ooi Tan

Published in: Genome medicine (2021)

Our results indicate that combining histone modification and functional assay data may provide a more accurate metric to assess enhancer activity than either platform individually, providing insights into the relative contribution of genetic (cis) and regulatory (trans) mechanisms to GC enhancer functional heterogeneity.

Keyphrases

high throughput
transcription factor
single cell
binding protein
big data
high resolution
genome wide
electronic health record
artificial intelligence