Pharmacological therapy and cardiovascular risk reduction for type 2 diabetes.
Eduardo Bello MartinsEduardo Gomes LimaFabio Grunspun PittaLeticia Neves Solon CarvalhoThiago Dias de QueirozCarlos Vicente SerranoPublished in: Revista da Associacao Medica Brasileira (1992) (2020)
The pharmacological therapy for type 2 diabetes mellitus has presented important advances in recent years, which has impacted the treatment of patients with established cardiovascular disease or with high cardiovascular risk. In this scenario, two drug classes have emerged and demonstrated clear clinical benefits: SGLT-2 inhibitors and GLP-1 agonists. The present review discusses the pharmacology, adverse effects, and clinical trials that have demonstrated the benefits of these medications in reducing cardiovascular risk.