Location of Gastrointestinal Stromal Tumor (GIST) in the Stomach Predicts Tumor Mutation Profile and Drug Sensitivity.
Ashwyn K SharmaJorge de la TorreNikki S IJzermanThomas Lee SuttonBeiqun ZhaoTahsin M KhanSudeep BanerjeeChristina L CuiVi NguyenMaha AlkhuziemPetur SnaebjornssonHester van BovenAnnemarie BruiningChih-Min TangHyunho YoonAlexa De la FuenteShumei KatoHitendra PatelMichael C HeinrichChristopher L CorlessSantiago HorganAdam M BurgoynePaul FantaJill P MesirovAndrew M BlakelyJeremy Lee DavisSkye C MayoWinan J van HoudtNeeltje SteeghsJason K SicklickPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2021)
We provide the first evidence that the mutational landscape of gastric GIST is related to tumor location. Proximal gastric GIST are overwhelmingly KIT mutant, irrespective of morphology or age, whereas distal tumors display non-KIT genomic diversity. Anatomic location of gastric GIST may therefore provide immediate guidance for clinical treatment decisions and selective confirmatory genomic testing when resources are limited.