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Objectively characterizing Huntington's disease using a novel upper limb dexterity test.

Samuel WoodgatePhilippa Morgan-JonesSusanne ClinchCheney DrewRebecca PlayleMohamed BennasarYulia HicksCatherine HoltAnne-Catherine Bachoud-LéviRenaud MassartDavid CraufurdNigel KirbyKaty HamanaRobin SchubertRalf ReilmannAnne E RosserMonica Busse
Published in: Journal of neurology (2021)
The C3t demonstrates promise as a simple, easy to administer, objective outcome measure capable of predicting impairment that is reflective of Huntington's disease severity and offers a viable solution to support remote clinical monitoring. It may also offer utility as a screening tool for recruitment to clinical trials given preliminary indications of association with the prognostic index normed for Huntington's disease.
Keyphrases
  • upper limb
  • clinical trial
  • physical activity
  • randomized controlled trial
  • big data