Objectively characterizing Huntington's disease using a novel upper limb dexterity test.
Samuel WoodgatePhilippa Morgan-JonesSusanne ClinchCheney DrewRebecca PlayleMohamed BennasarYulia HicksCatherine HoltAnne-Catherine Bachoud-LéviRenaud MassartDavid CraufurdNigel KirbyKaty HamanaRobin SchubertRalf ReilmannAnne E RosserMonica BussePublished in: Journal of neurology (2021)
The C3t demonstrates promise as a simple, easy to administer, objective outcome measure capable of predicting impairment that is reflective of Huntington's disease severity and offers a viable solution to support remote clinical monitoring. It may also offer utility as a screening tool for recruitment to clinical trials given preliminary indications of association with the prognostic index normed for Huntington's disease.