A Low Tumor Mutational Burden and PTEN Mutations Are Predictors of a Negative Response to PD-1 Blockade in MSI-H/dMMR Gastrointestinal Tumors.
Akihito KawazoeAkihito KawazoeMasahito KawazuToshihiro SuzukiYoshiaki NakamuraTetsuya NakatsuraTakeshi KuwataToshihide UenoYasutoshi KubokiDaisuke KotaniTakashi KojimaHiroya TaniguchiHiroyuki ManoMasafumi IkedaKohei ShitaraItaru EndoTakayuki YoshinoPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2021)
Low TMBs and PTEN mutations, especially mutations in the phosphatase domain associated with an immunosuppressive environment, were mutually exclusive and might be negative predictors of PD-1 blockade responses in patients with MSI-H/dMMR GI tumors.
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