Impaired airway epithelial cell wound-healing capacity is associated with airway remodelling following RSV infection in severe preschool wheeze.
Cecilia K AnderssonJua IwasakiJames CookPolly RobinsonPrasad NagakumarSofia MogrenLouise FlemingAndrew BushSejal SaglaniClare M LloydPublished in: Allergy (2020)
Despite increased anti-viral responses, preschool children with severe wheeze had impaired airway epithelial proliferative responses following damage. This might be connected to the low expression of EGFR in PSW which may affect epithelial function and contribute to asthma pathogenesis.