Staphylococcus aureus causes aberrant epidermal lipid composition and skin barrier dysfunction.
Jihyun KimByung Eui KimEvgeny V BerdyshevIrina BronovaLianghua BinJaewoong BaeSeokjin KimHye-Young KimUn-Ha LeeMyoung Shin KimHyunmi KimJinyoung LeeClifton F HallJessica Hui-BeckmanYunhee ChangAnna Sofia BronoffDasom HwangHae-Young LeeElena GolevaKangmo AhnDonald Y M LeungPublished in: Allergy (2023)
Aberrant skin lipid profiles and barrier dysfunction are associated with S. aureus colonization in AD patients. These effects are attributed to the inhibition of ELOVLs by S. aureus-induced IL-1β, TNF-α, IL-6, and IL-33 seen in keratinocyte models and are more prominent in MRSA than MSSA.
Keyphrases
- staphylococcus aureus
- end stage renal disease
- wound healing
- ejection fraction
- newly diagnosed
- oxidative stress
- chronic kidney disease
- soft tissue
- methicillin resistant staphylococcus aureus
- rheumatoid arthritis
- prognostic factors
- fatty acid
- high glucose
- diabetic rats
- escherichia coli
- patient reported outcomes
- cystic fibrosis