Randomized Secondary Prevention Trials in Participants With Symptomatic Intracranial Atherosclerotic Stenosis.
Lauren E DunnYan WangTareq Kass-HoutDavid ChiuPublished in: Stroke (2024)
Intracranial atherosclerotic stenosis is a prevalent cause of ischemic stroke worldwide. Its association with silent cerebral infarcts and its contribution to cognitive impairment and dementia emphasize the critical need for disease prevention and effective management strategies. Despite extensive research on secondary stroke prevention treatment over the past several decades, intracranial atherosclerotic stenosis continues to exhibit a notably higher recurrent stroke rate compared with other causes. This review focuses on randomized secondary prevention trials involving antithrombotic therapy, endovascular treatment, open surgical therapy, and remote ischemic conditioning. It aims to provide an insightful overview of the major findings from each trial and their implications for future research efforts.
Keyphrases
- atrial fibrillation
- cognitive impairment
- phase iii
- endovascular treatment
- double blind
- open label
- phase ii
- placebo controlled
- clinical trial
- optic nerve
- randomized controlled trial
- cerebral ischemia
- mild cognitive impairment
- minimally invasive
- study protocol
- stem cells
- quality improvement
- oxidative stress
- bone marrow
- cell therapy
- combination therapy