Connective tissue growth factor mediates transforming growth factor β-induced collagen expression in human endometrial stromal cells.
Mei-Leng CheongTsung-Hsuan LaiWen-Bin WuPublished in: PloS one (2019)
We reveal here that TGFβ1, collagen, and CTGF are expressed in the stroma of adenomyotic endometria and demonstrate that TGFβ1 can induce collagen production in endometrium-derived fibroblasts through cellular Smad2/3-dependent signaling pathway and CTGF expression, suggesting that endometrial TGFβ may take part in the pathogenesis of adenomyosis and ectopic endometrium may participate in uterine adenomyosis.
Keyphrases
- transforming growth factor
- epithelial mesenchymal transition
- growth factor
- poor prognosis
- signaling pathway
- endothelial cells
- wound healing
- high glucose
- tissue engineering
- endometrial cancer
- genome wide
- long non coding rna
- induced pluripotent stem cells
- cell proliferation
- induced apoptosis
- drug induced
- dna methylation