Epsin Nanotherapy Regulates Cholesterol Transport to Fortify Atheroma Regression.
Kui CuiXinlei GaoBeibei WangHao WuKulandaisamy ArulsamyYunzhou DongYuling XiaoXingya JiangMarina V MalovichkoKathryn LiQianman PengYao Wei LuBo ZhuRongbin ZhengScott WongDouglas B CowanMacRae F LintonSanjay SrivastavaJin-Jun ShiKaifu ChenHong ChenPublished in: Circulation research (2022)
Our findings suggest that targeting Epsins in lesional macrophages may offer therapeutic benefits for advanced atherosclerosis by reducing CD36-mediated lipid uptake and increasing ABCG1-mediated cholesterol efflux.