Establishment of a protocol to extend the lifespan of human hormone-secreting pituitary adenoma cells.

Aurora AielloMaria Francesca CassarinoSimona NanniAntonella SestaFrancesco FerraúClaudio GrassiMarco LosaFrancesco TrimarchiAlfredo PontecorviSalvatore CannavòFrancesca Pecori GiraldiAntonella Farsetti

Published in: Endocrine (2017)

Our attempt represents the first demonstration of successful lifespan extension of human growth hormone-secreting pituitary adenoma cells via co-transfection of hTERT and SV40T and paves the way to future attempts to obtain stable cell lines.

Keyphrases

growth hormone
induced apoptosis
endothelial cells
cell cycle arrest
induced pluripotent stem cells
randomized controlled trial
endoplasmic reticulum stress
cell death
signaling pathway
oxidative stress