New Approaches for Treatment of Advanced Extranodal NK/T-Cell Lymphoma.
Wu YiTianxin YangSisi LinRui HaoJin YuYing WangXiangming TongPublished in: Cancer management and research (2022)
Extranodal NK/T cell lymphoma (ENKL) is a rare subtype of lymphoma that shows a poor clinical outcome. The most common sites are the nasal cavity, nasopharynx, paranasal sinuses, tonsils and larynx. Because of P-glycoprotein expression on ENKL cells, ENKL is resistant to anthracycline-based chemotherapy. L-asparaginase-based chemotherapy with or without radiotherapy shows promising outcomes for advanced ENKL, but has limited efficacy in relapsed/refractory ENKL. immune-checkpoint inhibitors, histone deacetylase inhibitors, and monoclonal antibodies are being investigated. In this review, we summarize the new treatments for ENKL.
Keyphrases
- histone deacetylase
- locally advanced
- diffuse large b cell lymphoma
- induced apoptosis
- poor prognosis
- acute lymphoblastic leukemia
- radiation therapy
- type diabetes
- squamous cell carcinoma
- multiple myeloma
- cell cycle arrest
- mass spectrometry
- high resolution
- rectal cancer
- metabolic syndrome
- signaling pathway
- skeletal muscle
- nk cells
- combination therapy
- endoplasmic reticulum stress
- weight loss
- replacement therapy