FTH promotes the proliferation and renders the HCC cells specifically resist to ferroptosis by maintaining iron homeostasis.

Wanye HuChaoting ZhouQiangan JingYancun LiJing YangChen YangLuyang WangJiayu HuHuanjuan LiHairui WangChen YuanYi ZhouXueying RenXiangmin TongJing DuYing Wang

Published in: Cancer cell international (2021)

These results provide new insights that FTH acts as an oncogene in the carcinogenesis and progression of HCC, and is hopeful to be a potential target for therapeutic intervention through ferroptosis.

Keyphrases

cell death
cell cycle arrest
induced apoptosis
randomized controlled trial
signaling pathway
endoplasmic reticulum stress
oxidative stress
pi k akt
risk assessment
climate change