Deuterium Metabolic Imaging Reports on TERT Expression and Early Response to Therapy in Cancer.
Georgios BatsiosCarter J BargerMeryssa TranNicholas SteversCarter BargerAnne Marie GillespieSabrina M RonenJoseph F CostelloPavithra ViswanathPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2022)
Elevated NADH is a metabolic consequence of TERT expression in cancer. Importantly, [U-2H]-pyruvate reports on early response to therapy, prior to anatomic alterations, thereby providing clinicians with a novel tool for assessment of tumor burden and treatment response in cancer.