Human epididymis protein 4 (HE4) is a novel biomarker for fibrosis in IgG4-related disease and can predict poor prognosis.
Songxin YanYu PengZiyan WuHui LuShengwei MoXianlong ChenYuan HuangXiaomeng LiWen ZhangYongzhe LiPublished in: RMD open (2022)
Our results demonstrate that HE4 can be used as a biomarker for IgG4-RD as it is correlated with diverse baseline clinical features, internal organ damage and degree of fibrosis in affected organs, and can predict poor prognosis.