Pretreatment Glasgow prognostic score predicts survival among patients with high PD-L1 expression administered first-line pembrolizumab monotherapy for non-small cell lung cancer.
Hisao ImaiTakayuki KishikawaHiroyuki MinemuraYutaka YamadaTatsuya IbeOu YamaguchiAtsuto MouriYoichiro HamamotoKenya KanazawaTakashi KasaiKyoichi KairaTakayuki KaburagiKoichi MinatoKunihiko KobayashiHiroshi KagamuPublished in: Cancer medicine (2021)
Among patients with high PD-L1 expression undergoing first-line pembrolizumab monotherapy for NSCLC, the GPS is significantly correlated with both PFS and OS, and BMI with OS, indicating that they could be used to predict treatment outcome in these patients. To the best of our knowledge, this is the first study to assess the relationship among the GPS, NLR, and BMI and survival among patients with high PD-L1 expression undergoing first-line pembrolizumab monotherapy for NSCLC.
Keyphrases
- advanced non small cell lung cancer
- small cell lung cancer
- combination therapy
- end stage renal disease
- body mass index
- open label
- ejection fraction
- healthcare
- chronic kidney disease
- newly diagnosed
- prognostic factors
- weight gain
- free survival
- randomized controlled trial
- physical activity
- patient reported outcomes
- weight loss