Longitudinal monitoring of somatic genetic alterations in circulating cell-free DNA during treatment with epidermal growth factor receptor-tyrosine kinase inhibitors.

Eiji IwamaKazuko SakaiNoriko HidakaKoji InoueAkiko FujiiNoriaki NakagakiKeiichi OtaRyo ToyozawaKoichi AzumaKeita NakatomiTaishi HaradaJunko HisasueShinya SakataTakayuki ShimoseJunji KishimotoYoichi NakanishiKazuto NishioIsamu Okamoto

Published in: Cancer (2019)

Liquid biopsy shows potential for prediction of EGFR-TKI efficacy and elucidation of clonal tumor evolution during targeted therapy.

Keyphrases

epidermal growth factor receptor
tyrosine kinase
advanced non small cell lung cancer
copy number
chronic myeloid leukemia
genome wide
ultrasound guided
ionic liquid
cross sectional
fine needle aspiration
small cell lung cancer