Altered hippocampal kynurenine pathway metabolism contributes to hyperexcitability in human mesial temporal lobe epilepsy-hippocampal sclerosis.

Soumil DeyAparna Banerjee DixitManjari TripathiRamesh Sharanappa DoddamaniMehar Chand SharmaSanjeev LalwaniPoodipedi Sarat ChandraJyotirmoy Banerjee

Published in: British journal of pharmacology (2021)

Our findings indicate that altered metabolism of tryptophan-kynurenine pathway metabolites in hippocampus could contribute to hyperglutamatergic tone in patients with MTLE-HS.

Keyphrases

temporal lobe epilepsy
endothelial cells
ms ms
induced pluripotent stem cells
cerebral ischemia
pluripotent stem cells
brain injury
blood brain barrier